I was fishing on the Willamette SE of Eugene a couple weeks ago, not having a particularly good day. I started at one spot I am convinced holds fish. After fishing there for a few hours with no success and not seeing any fish either I moved to another spot on the river. Between these two spots and better than 4 hours fishing I think I ran through every fly in my box. I tried big nymphs, small nymphs, emergers, and dries and only managed to catch couple of fingerlings.
Eventually I even tried throwing this into the river...